Pusoon Chun Selected Research

Monophenol Monooxygenase (Tyrosinase)

5/2022	Identification of a Novel Class of Anti-Melanogenic Compounds, (Z)-5-(Substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one Derivatives, and Their Reactive Oxygen Species Scavenging Activities.
1/2022	Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies.
5/2021	Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety.
1/2021	In vitro anti-melanogenic effects of chimeric compounds, 2-(substituted benzylidene)-1,3-indanedione derivatives with a β-phenyl-α, β -unsaturated dicarbonyl scaffold.
1/2019	Antioxidant, anti-tyrosinase and anti-melanogenic effects of (E)-2,3-diphenylacrylic acid derivatives.
1/2019	Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in α-MSH-stimulated B16F10 melanoma cells.
1/2019	Tyrosinase inhibition and anti-melanin generation effect of cinnamamide analogues.
1/2019	Inhibitory effects of N-(acryloyl)benzamide derivatives on tyrosinase and melanogenesis.
11/2018	Design, synthesis and anti-melanogenic effect of cinnamamide derivatives.
10/2018	A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells.

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Pusoon Chun Research Topics

Disease

21	Melanoma (Melanoma, Malignant) 05/2022 - 07/2012
8	Inflammation (Inflammations) 05/2021 - 01/2013
7	Hyperpigmentation 01/2021 - 10/2013
6	Neoplasms (Cancer) 10/2018 - 08/2010
5	Pigmentation Disorders (Ito Syndrome) 01/2019 - 10/2013
5	Insulin Resistance 01/2018 - 01/2013
4	Body Weight (Weight, Body) 05/2021 - 01/2013
3	Fibrosis (Cirrhosis) 12/2020 - 01/2015
2	Obesity 01/2018 - 01/2017
2	Melanosis (Freckles) 01/2018 - 10/2013
2	Type 2 Diabetes Mellitus (MODY) 01/2018 - 01/2013
2	Fatty Liver 01/2018 - 01/2018
2	Chronic Obstructive Pulmonary Disease (COPD) 05/2015 - 01/2015
2	Colonic Neoplasms (Colon Cancer) 03/2014 - 01/2014
2	Breast Neoplasms (Breast Cancer) 01/2014 - 10/2011
1	Atrial Fibrillation 12/2020
1	Heart Diseases (Heart Disease) 12/2020
1	Cardiomegaly (Heart Hypertrophy) 12/2020
1	Heart Failure 12/2020
1	Hypertension (High Blood Pressure) 12/2020
1	Myocardial Infarction 12/2020
1	Atrial Remodeling 12/2020
1	Adenocarcinoma 10/2018
1	Kidney Diseases (Kidney Disease) 02/2018
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 02/2018
1	Renal Cell Carcinoma (Grawitz Tumor) 02/2018
1	Lupus Nephritis 02/2018
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2018
1	Non-alcoholic Fatty Liver Disease 01/2018
1	Weight Gain 01/2017
1	Hyperinsulinism (Hyperinsulinemia) 01/2017
1	Dyslipidemias (Dyslipidemia) 01/2017
1	Lymphoma (Lymphomas) 06/2015
1	Hematologic Neoplasms (Hematological Malignancy) 06/2015
1	Osteoporosis 01/2015
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015
1	Colorectal Neoplasms (Colorectal Cancer) 03/2014
1	Experimental Melanoma 10/2013
1	Skin Diseases (Skin Disease) 10/2013

Drug/Important Bio-Agent (IBA)

23	Monophenol Monooxygenase (Tyrosinase)IBA 05/2022 - 07/2012
18	Melanins (Melanin)IBA 05/2022 - 07/2012
9	Melanocyte-Stimulating Hormones (MSH)IBA 05/2021 - 07/2012
4	kojic acidIBA 05/2022 - 01/2019
4	Histone Deacetylase InhibitorsIBA 12/2020 - 08/2010
4	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2018 - 01/2013
3	1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)IBA 05/2021 - 03/2018
3	Histone Deacetylases (Histone Deacetylase)IBA 12/2020 - 08/2010
3	Insulin (Novolin)FDA Link 01/2018 - 01/2013
2	Therapeutic UsesIBA 12/2020 - 02/2018
2	Triglycerides (Triacylglycerol)IBA 01/2018 - 01/2013
2	Sirtuin 1IBA 01/2018 - 01/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 01/2013
2	AcidsIBA 01/2018 - 01/2013
2	NAD (NADH)IBA 01/2018 - 01/2015
2	LipidsIBA 01/2018 - 01/2018
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 07/2017
2	NF-kappa B (NF-kB)IBA 10/2017 - 01/2014
2	Vorinostat FDA Link 06/2015 - 08/2010
2	SirtuinsIBA 05/2015 - 01/2015
2	Proteins (Proteins, Gene)FDA Link 01/2015 - 01/2014
2	N1- hydroxy- N8- (4- phenoxyphenyl)octanediamideIBA 01/2014 - 08/2010
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2014 - 10/2011
2	Hydroxamic Acids (Hydroxamic Acid)IBA 01/2014 - 08/2010
2	(Z)- 5- (2,4- dihydroxybenzylidene)thiazolidine- 2,4- dioneIBA 10/2013 - 08/2013
1	MHY3200IBA 05/2021
1	Bleaching AgentsIBA 01/2021
1	ArbutinIBA 01/2019
1	AmidesIBA 01/2019
1	Reducing AgentsIBA 10/2018
1	Bovine Serum AlbuminIBA 10/2018
1	GoldIBA 10/2018
1	galanginIBA 01/2018
1	EnzymesIBA 01/2018
1	ResveratrolIBA 01/2018
1	SRT1720IBA 01/2018
1	AntioxidantsIBA 10/2017
1	barbituric acid (barbiturate)IBA 10/2017
1	propionic acid (potassium propionate)IBA 01/2017
1	Hormones (Hormone)IBA 01/2017
1	Carboxylic AcidsIBA 09/2015
1	ThiazolidinesIBA 09/2015
1	romidepsin (FK228)FDA Link 06/2015
1	Antineoplastic Agents (Antineoplastics)IBA 06/2015
1	belinostatIBA 06/2015
1	GasesIBA 01/2015
1	Skin Lightening PreparationsIBA 01/2015
1	CosmeticsIBA 01/2015
1	MHY336IBA 03/2014
1	Transcription Factors (Transcription Factor)IBA 01/2014
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2014
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2014
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2014
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2014
1	anthraceneIBA 01/2014
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2014
1	Caspase 3 (Caspase-3)IBA 01/2014
1	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 08/2013
1	4- (6,7- dihydro- 5H- indeno(5,6- d)thiazol- 2- yl)benzene- 1,3- diolIBA 07/2013

Therapy/Procedure

2	Chemoprevention 03/2014 - 01/2014